《Heterocycles 45.Synthesis, characterization and biological evaluation of 3-indolyl-1-pyridyl-2-propenones as anticancer agents》 was published in Farmacia (Bucharest, Romania) in 2020. These research results belong to Kamga, Justin; Leonte, Denisa; Ambassa, Pantaleon; Mbaveng, Armelle T.; Fotso, Ghislain W.; Coman, Fana-Maria; Ngadjui, Bonaventure T.; Kuete, Victor; Zaharia, Valentin; Ngameni, Bathelemy. Category: pyridine-derivatives The article mentions the following:
A series of seven indolyl pyridyl propenones I [R = H, Me, Et, etc.; Ar = 3-pyridyl, 4-pyridyl] were synthesized via Claisen-Schmidt condensation with 68.8-91.8% yields. All the synthesized compounds I were purified and characterized by m.ps., IR, 1H NMR, 13C NMR and HRMS. The cytotoxicity of the synthesized indolyl pyridyl propenones I and doxorubicin, used as pos. control, was determined in a panel of nine human cancer cell lines including both sensitive and drug-resistant phenotypes, as well as in normal AML12 hepatocytes. Compounds I [R = Et, allyl; Ar = 4-pyridyl] and [R = Me; Ar = 3-pyridyl] displayed half maximal inhibitory concentration (IC50) values below 100μM in all tested cancer cell lines meanwhile, other compounds displayed selective activities. The experimental process involved the reaction of 4-Acetylpyridine(cas: 1122-54-9Category: pyridine-derivatives)
4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Category: pyridine-derivatives