Kanchanadevi, Sivaswamy published the artcileRuthenium(III) hydrazone complexes with triphenylphosphine/triphenylarsine co-ligands: Synthesis, DNA/BSA binding, antioxidative and cytotoxic activity, Recommanded Product: Phenyl(pyridin-2-yl)methanone, the publication is Inorganica Chimica Acta (2021), 120532, database is CAplus.
New ruthenium(III) complexes with (E)-3-methoxy-N’-(phenyl(pyridin-2-yl)methylene)benzohydrazide (HL) were synthesized and characterized by various physicochem. and spectroscopic methods. The ligand acted as a tridentate, monobasic chelating ligand with NNO donor sites in all the complexes. The x-ray crystal structure of one of the complexes, [RuIII(L)(PPh3)Cl2] (1) demonstrated a distorted octahedral coordination geometry around the metal center. Interactions of these complexes with calf thymus-DNA (CT-DNA) assessed by absorption and emission spectroscopy revealed intercalative mode of binding. Bovine serum albumin (BSA) binding of the ligand and complexes studied by absorption spectroscopy, fluorescence and synchronous spectroscopic methods revealed that the compounds bind to BSA via static binding. Antioxidant study of the ligand and complexes showed significant antioxidant activity against DPPH radical. In addition, the in vitro cytotoxicity of the ligand and complexes against human breast cancer cell line (MCF-7) and human lung cancer cells (A-549) was assayed. The results showed higher cytotoxic activity with lower IC50 values indicating their efficiency in killing the cancer cells even at low concentrations
Inorganica Chimica Acta published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Recommanded Product: Phenyl(pyridin-2-yl)methanone.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem