In 2017,Kanishchev, Oleksandr S.; Dolbier, William R. Jr. published 《Ni/Ir-Catalyzed Photoredox Decarboxylative Coupling of S-Substituted Thiolactic Acids with Heteroaryl Bromides: Short Synthesis of Sulfoxaflor and Its SF5 Analog》.Chemistry – A European Journal published the findings.Reference of 5-Bromo-2-chloropyridine The information in the text is summarized as follows:
The Ni/Ir-catalyzed photoredox decarboxylative coupling of readily available S-substituted thiolactic acids such as S-Me thiolactic acid, S-Ph thiolactic acid, 2-(phenylsulfonyl)propanoic acid, etc. with electron-deficient heteroaryl bromides XBr (X = pyrimidin-2-yl, 5-cyanopyridin-2-yl, 4-F3CC6H4, etc.), resulted in the formation of simple but otherwise not easily accessible heteroarenes with alkylsulfide side chains XCH(CH3)SY (Y = Me, Ph). To demonstrate a practical use of this coupling reaction, its efficiency in the one-step synthesis of a key intermediate is shown in the synthesis of the recently marketed insecticide Sulfoxaflor, and for the short synthesis of SF5-Sulfoxaflor. The experimental process involved the reaction of 5-Bromo-2-chloropyridine(cas: 53939-30-3Reference of 5-Bromo-2-chloropyridine)
5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Reference of 5-Bromo-2-chloropyridine