Karges, Johannes; Kalaj, Mark; Gembicky, Milan; Cohen, Seth M. published the artcile< ReI tricarbonyl complexes as coordinate covalent inhibitors for the SARS-CoV-2 main cysteine protease>, Product Details of C10H6Cl2N2, the main research area is rhenium tricarbonyl complex coordinate inhibitor main protease SARS CoV2; synthesis crystal structure rhenium tricarbonyl complex protease inhibitor 3CLpro; SARS-CoV-2; antiviral agents; bioinorganic chemistry; medicinal inorganic chemistry; protease inhibitor.
Since its outbreak, the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has impacted the quality of life and cost hundreds-of-thousands of lives worldwide. Based on its global spread and mortality, there is an urgent need for novel treatments which can combat this disease. To date, the 3-chymotrypsin-like protease (3CLpro), which is also known as the main protease, is considered among the most important pharmacol. targets. The vast majority of investigated 3CLpro inhibitors are organic, non-covalent binders. Herein, the use of inorganic, coordinate covalent binders is proposed that can attenuate the activity of the protease. ReI tricarbonyl complexes were identified that demonstrate coordinate covalent enzymic inhibition of 3CLpro. Preliminary studies indicate the selective inhibition of 3CLpro over several human proteases. This study presents the first example of metal complexes as inhibitors for the 3CLpro cysteine protease.
Angewandte Chemie, International Edition published new progress about Anticoronaviral agents. 1762-41-0 belongs to class pyridine-derivatives, and the molecular formula is C10H6Cl2N2, Product Details of C10H6Cl2N2.