Synthetic Route of C6H7Br2NIn 2018 ,《Catalytic Synthesis of Indolines by Hydrogen Atom Transfer to Cobalt(III)-Carbene Radicals》 was published in Chemistry – A European Journal. The article was written by Karns, Alexander S.; Goswami, Monalisa; de Bruin, Bas. The article contains the following contents:
A new method was reported for the synthesis of tert-butyl-2-arylindoline-1-carboxylates such as I [R = Ph, 4-MeOC6H4, 2-pyridyl, etc.; R1 = H, 4-Me, 5-MeO, 5-CF3] from ring-closing reaction of o-aminoarylidine-N-tosylhydrazones II proceeded through cobalt(III)-carbene radical intermediate via rapid intramol. 1,5-hydrogen atom transfer (1,5-HAT). This methodol. employed the use of inexpensive com. available reagents and allowed the transformation of easily derivatized benzaldehyde-derived precursors to functionalized indoline products via formation of compounds II. This transformation was the first reported example of the synthesis of nitrogen-containing heterocycles from cobalt(III)-carbene radical precursors. Computational investigations using d. functional theory identified remarkably low barriers for 1,5-HAT and subsequent radical rebound displacement, hence provided support for the proposed mechanism. Furthermore, the steric and electronic effects of substituents on aniline ring and on nitrogen atom were evaluated and highlighted the importance of adequate resonance stabilization of radical intermediates to the success of this transformation. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Synthetic Route of C6H7Br2N)
2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Synthetic Route of C6H7Br2N