Kawatsura, Motoi published the artcileTransition Metal-Catalyzed Addition of Amines to Acrylic Acid Derivatives. A High-Throughput Method for Evaluating Hydroamination of Primary and Secondary Alkylamines, Application of 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, the publication is Organometallics (2001), 20(10), 1960-1964, database is CAplus.
Several new classes of transition metal-catalyzed reactions of amines with the C:C bond of acrylic acid derivatives were discovered using a high-throughput colorimetric assay. This assay is general for the reactions of primary and secondary alkylamines with acrylic acid derivatives, and the screening of potential catalysts using this assay revealed a number of different metal/ligand combinations that promote these hydroaminations. The colorimetric assay revealed catalysts for the addition of piperidine to methacrylonitrile, crotononitrile, Et crotonate, and Et methacrylate, as well as catalysts for reactions of butylamine and aniline with methacrylonitrile, with product yields of 89-99%. A catalyst for the addition of aniline to crotononitrile at 100° was also discovered. Thus, treating crotononitrile with aniline in presence of 10% Pd(OAc)2 and 10% 1,3-bis[(di-tert-butylphosphino)methyl]benzene gave 90% 2-anilinopropyl cyanide. The products of these reactions are basic building blocks for the synthesis of β-amino acids, amino alcs., and diamines. These reactions may ultimately produce an enantioselective route to optically active difunctional materials from commodity reagents.
Organometallics published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C23H43NP2, Application of 2,6-Bis((di-tert-butylphosphino)methyl)pyridine.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem