Directed Lithiation of 3-[(tert-Butoxycarbonyl)amino]-2-methoxypyridines: Synthetic Route to Nevirapine and Its 4-Substituted Derivatives was written by Kelly, Terence A.;Patel, Usha R.. And the article was included in Journal of Organic Chemistry in 1995.Synthetic Route of C7H10N2O This article mentions the following:
The directed lithiation of 3-[(tert-butoxycarbonyl)amino]-2-methoxypyridines produces a variety of 4-substituted derivatives A general route to 4-substituted dipyridodiazepinones, culminating in the synthesis of the antiviral nevirapine (I) is demonstrated. In the experiment, the researchers used many compounds, for example, 2-Methoxy-4-methylpyridin-3-amine (cas: 76005-99-7Synthetic Route of C7H10N2O).
2-Methoxy-4-methylpyridin-3-amine (cas: 76005-99-7) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 閳?8.7 鑴?10閳? cm3璺痬ol閳?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ璺痬ol閳? in the liquid phase and 140.4 kJ璺痬ol閳? in the gas phase. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Synthetic Route of C7H10N2O