《Influence of Ligand and Nuclearity on the Cytotoxicity of Cyclometallated C-N-C Platinum(II) Complexes》 was written by Kergreis, Angelique; Lord, Rianne M.; Pike, Sarah J.. Product Details of 626-05-1 And the article was included in Chemistry – A European Journal in 2020. The article conveys some information:
A series of cyclometalated mono- and di-nuclear platinum(II) complexes [(C-N-C)PtL] (2-3, L = DMSO, PPh3) and the parent organic ligand, 2,6-diphenylpyridine (1, HC-N-CH), have been synthesized and characterized. This library of compounds includes [(C-N-C)PtII(L)] (2, 3; L = DMSO, PPh3) and [(C-N-C)2Pt2(μ-L1)] (4-6; L1 = pyrazine, 4,4′-bipyridine, dppb). Their cytotoxicity was assessed against four cancerous cell lines and one normal cell line, with results highlighting significantly increased antiproliferative activity for the dinuclear complexes 4-6, when compared to the mononucleated species 2 and 3. Complex 6 is the most promising candidate, displaying very high selectivity towards cancerous cells, with selectivity index (SI) values >29.5 (A2780) and >11.2 (A2780cisR), and outperforming cisplatin by >4-fold and >18-fold, resp. The results came from multiple reactions, including the reaction of 2,6-Dibromopyridine(cas: 626-05-1Product Details of 626-05-1)
2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Product Details of 626-05-1