Khan, Ismat Ullah; Kattela, Shivashankar; Hassan, Abbas; Correia, Carlos Roque Duarte published the artcile< Enantioselective total synthesis of the highly selective sphingosine-1-receptor VPC01091 by the Heck desymmetrization of a non-activated cyclopentene-fused spiro-pyrrolidinone>, Application of C13H15F3N2O, the main research area is stereoselective Heck Matsuda desymmetrization cyclopentene fused spiropyrrolidinone arenediazonium tetrafluoroborate; enantioselective total synthesis VPC01091.
A novel, efficient and enantioselective Heck-Matsuda desymmetrization of non-activated cyclopentene-fused spiro-pyrrolidinones was developed. The reaction provided the Heck products in good to excellent yields and selectivities and tolerated a variety of functional groups in arenediazonium tetrafluoroborates (12 examples) with respect to its electronics and substitution patterns. This methodol. was successfully applied in the concise enantioselective total synthesis of VPC01091 (I), a drug candidate for the treatment of multiple sclerosis.
Organic & Biomolecular Chemistry published new progress about Desymmetrization. 1428537-19-2 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Application of C13H15F3N2O.