Pd-Catalyzed regio- and enantioselective allylic substitution with 2-pyridones was written by Khan, Sardaraz;Shah, Babar Hussain;Khan, Ijaz;Li, Meiqi;Zhang, Yong Jian. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.Quality Control of 3,5-Dibromo-2-hydroxypyridine This article mentions the following:
An efficient method for the asym. synthesis of N-substituted 2-pyridones via Pd-catalyzed regio- and enantioselective allylic substitution of hydroxyl-containing allylic carbonates with 2-pyridones were developed. By using a palladium complex in-situ generated from Pd2(dba)3璺疌HCl3 and phosphoramidite as a ligand, the process allowed rapid access to N-substituted 2-pyridones with complete chemo- and regioselectivities and good to high enantioselectivities. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6Quality Control of 3,5-Dibromo-2-hydroxypyridine).
3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Quality Control of 3,5-Dibromo-2-hydroxypyridine