Khandazhinskaya, Anastasia et al. published their research in Organic & Biomolecular Chemistry in 2021 | CAS: 257937-08-9

tert-Butyl (3-bromopyridin-4-yl)carbamate (cas: 257937-08-9) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Computed Properties of C10H13BrN2O2

Novel fleximer pyrazole-containing adenosine analogues: chemical, enzymatic and highly efficient biotechnological synthesis was written by Khandazhinskaya, Anastasia;Eletskaya, Barbara;Fateev, Ilja;Kharitonova, Maria;Konstantinova, Irina;Barai, Vladimir;Azhayev, Alex;Hyvonen, Mervi T.;Keinanen, Tuomo A.;Kochetkov, Sergey;Seley-Radtke, Katherine;Khomutov, Alex;Matyugina, Elena. And the article was included in Organic & Biomolecular Chemistry in 2021.Computed Properties of C10H13BrN2O2 This article mentions the following:

Nucleoside analogs have long served as key chemotherapeutic drugs for the treatment of viral infections and cancers. Problems associated with the development of drug resistance have led to a search for the design of nucleosides capable of bypassing point mutations in the target enzyme’s binding site. As a possible answer to this, the Seley-Radtke group developed a flexible nucleoside scaffold (fleximers), where the heterocyclic purine base is split into its two components, i.e. pyrimidine and imidazole. Herein, we present a series of new pyrazole-containing flex-bases and the corresponding fleximer analogs of 8-aza-7-deaza nucleosides. Subsequent studies found that pyrazole-containing flex-bases are substrates of purine nucleoside phosphorylase (PNP). We have compared the chem. synthesis of fleximers and enzymic approaches with both isolated enzymes and the use of E. coli cells over-producing PNP. The latter provided stereochem. pure pyrazole-containing β-D-ribo- and β-D-2′-deoxyribo-fleximers and are beneficial in terms of environmental issues, are more economical, and streamline the steps required from a chem. approach. The reaction is carried out in water, avoiding hazardous chems., and the products are isolated by ion-exchange chromatog. using water/ethanol mixtures for elution. Moreover, the target nucleosides were obtained on a multi-milligram scale with >97-99% purity, and the reactions can be easily scaled up. In the experiment, the researchers used many compounds, for example, tert-Butyl (3-bromopyridin-4-yl)carbamate (cas: 257937-08-9Computed Properties of C10H13BrN2O2).

tert-Butyl (3-bromopyridin-4-yl)carbamate (cas: 257937-08-9) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Computed Properties of C10H13BrN2O2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem