Kim, Jin-Ock et al. published their research in International Journal of Biological Macromolecules in 2020 | CAS: 104-73-4

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Reference of 104-73-4

Development and characterization of a fully human antibody targeting SCF/c-kit signaling was written by Kim, Jin-Ock;Kim, Ha-Neul;Kim, Kwang-Hyeok;Baek, Eun Ji;Park, Jeong-Yang;Ha, Kyungsoo;Heo, Deok Rim;Seo, Min-Duk;Park, Sang Gyu. And the article was included in International Journal of Biological Macromolecules in 2020.Reference of 104-73-4 This article mentions the following:

CD117/c-kit, a tyrosine kinase receptor, plays a critical role in hematopoiesis, pigmentation, and fertility. The overexpression and activation of c-kit are thought to promote tumor growth and have been reported in various cancers, including leukemia, glioblastoma and mastocytosis. To disrupt the SCF/c-kit signaling axis in cancer, we generated a c-kit antagonist human antibody (NN2101) that binds to domain 2/3 of c-kit. In addition, the examination of binding affinity using surface plasmon resonance (SPR) assay showed that NN2101 can bind to c-kit of monkeys (KD = 2.92 x 10-10 M), rats (KD = 1.68 x 10-6 M), mice (KD = 11.5 x 10-9 M), and humans (KD = 2.83 x 10-12 M). We showed that NN2101 does not cause antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity. The immunogenicity of NN2101 was similar to that of bevacizumab. Furthermore, the crystal structure of NN2101 Fab was determined and the structure of NN2101 Fab:c-kit complex was modeled. Structural information, as well as mutagenesis results, revealed that NN2101 can bind to the SCF-binding regions of c-kit. Collectively, we generated a c-kit neutralizing human antibody (NN2101) for the treatment of erythroleukemia and characterized its biophys. properties. NN2101 can potentially be used as a therapeutic antibody to treat different cancers. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Reference of 104-73-4).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Reference of 104-73-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem