In 2018,Kim, Jun Ki; Lim, Hwan Jung; Jeong, Kyung Chae; Park, Seong Jun published 《One-pot sequential synthesis of tetrasubstituted thiophenes via sulfur ylide-like intermediates》.Beilstein Journal of Organic Chemistry published the findings.HPLC of Formula: 31106-82-8 The information in the text is summarized as follows:
A novel approach for the practical synthesis of tetrasubstituted thiophenes was developed. The mechanism for this reaction was based on the formation of a sulfur ylide-like intermediate. It was clearly suggested by (i) the intramol. cyclization of ketene N,S-acetals to the corresponding thiophenes, (ii) 1H NMR studies of Meldrum’s acid-substituted aminothioacetals and (iii) substitution studies of the methoxy group on Meldrum’s acid containing N,S-acetals. Notably, in terms of structural effects on the reactivity and stability of sulfur ylide-like intermediates, 2-pyridyl substituted compound exhibited superior properties over those of others. In the experiment, the researchers used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8HPLC of Formula: 31106-82-8)
2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. HPLC of Formula: 31106-82-8