《Phenotypic Discovery of an Antivirulence Agent against Vibrio vulnificus via Modulation of Quorum-Sensing Regulator SmcR》 was published in ACS Infectious Diseases in 2020. These research results belong to Kim, Seung Min; Park, Jongmin; Kim, Myun Soo; Song, Heebum; Jo, Ala; Park, Hankum; Kim, Tae Sung; Choi, Sang Ho; Park, Seung Bum. Formula: C5H3Br2N The article mentions the following:
An antivirulence agent against Vibrio vulnificus named quoromycin (QM, I) was discovered by a phenotype-based elastase inhibitor screening. Using the fluorescence difference in two-dimensional gel electrophoresis (FITGE) approach, SmcR, a quorum-sensing master regulator and homolog of LuxR, was identified as the target protein of QM. We confirmed that the direct binding of QM to SmcR inhibits the quorum-sensing signaling pathway by controlling the DNA-binding affinity of SmcR and thus effectively alleviates the virulence of V. vulnificus in vitro and in vivo. I can be regarded as a novel antivirulence agent for the treatment of V. vulnificus infection. In the part of experimental materials, we found many familiar compounds, such as 2,5-Dibromopyridine(cas: 624-28-2Formula: C5H3Br2N)
2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Formula: C5H3Br2N