Kiselyov, Alexander S.’s team published research in Tetrahedron Letters in 46 | CAS: 107263-95-6

Tetrahedron Letters published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C6H5F4NO3S, Formula: C6H5F4NO3S.

Kiselyov, Alexander S. published the artcileA novel three-component reaction of N-fluoropyridinium salts: a facile approach to imidazo[1,2-a]pyridines, Formula: C6H5F4NO3S, the publication is Tetrahedron Letters (2005), 46(26), 4487-4490, database is CAplus.

The reaction of N-fluoropyridinium triflates I (R1 = H, 2-Me, 4-Me2CH, 2-Ph, 3-Cl, etc.) with isonitriles R2NC (R2 = Me2CH, Me3C, EtO2CH2, cyclohexyl, Ph, PhCH2, etc.) in acetonitrile or propionitrile in the presence of NaBH(OAc)3 led to the formation of the corresponding imidazo[1,2-a]pyridines II (R3 = Me, Et) in 44-73% yields. The proposed reaction mechanism involves the intermediate formation of a highly reactive carbene species and apparent reduction of the pyridinium intermediate with NaBH(OAc)3 to yield the targeted heterocycles.

Tetrahedron Letters published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C6H5F4NO3S, Formula: C6H5F4NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem