Kiss, Levente; Pop, Alexandra; Shova, Sergiu; Rat, Ciprian I.; Silvestru, Cristian published the artcile< Synthesis and characterization of [4-{(CH2O)2CH}C6H4]2Hg, [4-(O:CH)C6H4]2Hg and [(E)-4-(RN:CH)C6H4]2Hg (R = 2'-py, 4'-py, 2'-pyCH2, 4'-pyCH2)>, Synthetic Route of 3731-53-1, the main research area is crystal structure mol mercury diaryl compound supramol preparation homocoupling.
The reaction of 4-[(CH2O)2CH]C6H4Br (1) with n-BuLi, followed by addition of HgCl2 to the in situ formed organolithium derivative, affords [4-{(CH2O)2CH}C6H4]2Hg (2). Deprotection of the formyl groups of 2 in presence of p-TsOH (p-Ts = 4-MeC6H4SO3) leads to [4-(O:CH)C6H4]2Hg (3). Condensation reactions of 3 with 2-aminopyridine (2-pyNH2), 4-aminopyridine (4-pyNH2), 2-aminomethylpyridine (2-pyCH2NH2), and 4-aminomethylpyridine (4-pyCH2NH2), in CH2Cl2, affords the novel diorganomercury(II) compounds of type [(E)-4-(RN:C)C6H4]2Hg [R = 2′-py (4), 4′-py (5), 2′-pyCH2- (6), 4′-pyCH2 (7)]. Compounds 2 and 3 were useful precursors for the preparation of the corresponding homocoupling products [4-{(CH2O)2CH}C6H4]2 (8) and [4-(O:CH)C6H4]2 (9) in presence of catalytic amounts of palladium(II) acetate. Compounds 2-9 were characterized by multinuclear magnetic resonance (NMR) (1H, 13C{1H}, and 199Hg{1H}, when appropriate) and IR (IR) spectroscopy and by mass spectrometry. The mol. structures of 3, 5, 6, 8, and 9 were determined by single-crystal X-ray diffraction.
Applied Organometallic Chemistry published new progress about Condensation reaction. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Synthetic Route of 3731-53-1.