Klake, Raphael K.; Gargaro, Samantha L.; Gentry, Skyler L.; Elele, Sharon O.; Sieber, Joshua D. published the artcile< Development of a Strategy for Linear-Selective Cu-Catalyzed Reductive Coupling of Ketones and Allenes for the Synthesis of Chiral γ-Hydroxyaldehyde Equivalents>, HPLC of Formula: 350-03-8, the main research area is chirality hydroxyaldehyde linear preparation copper catalyst reductive coupling equivalent; ketone allene reductive coupling copper catalyst.
The authors report the development of a stereoselective method for the allylation of ketones using N-substituted allyl equivalent generated from a chiral allenamide. By choice of the appropriate ligand for the Cu-catalyst, high linear selectivity can be obtained with good diastereocontrol. This methodol. allows access to chiral γ-hydroxyaldehyde equivalent that were applied in the synthesis of chiral γ-lactones and 2,5-disubstitued tetrahydrofurans.
Organic Letters published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation) (γ-Hydroxyaldehyde). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, HPLC of Formula: 350-03-8.