Name: 2-(Chloromethyl)-4-methoxypyridine hydrochlorideOn March 20, 1992, Kohl, Bernhard; Sturm, Ernst; Senn-Bilfinger, Joerg; Simon, W. Alexander; Krueger, Uwe; Schaefer, Hartmann; Rainer, Georg; Figala, Volker; Klemm, Kurt published an article in Journal of Medicinal Chemistry. The article was 《(H+, K+)-ATPase inhibiting 2-[(2-pyridylmethyl)sulfinyl]benzimidazoles. 4. A novel series of dimethoxypyridyl-substituted inhibitors with enhanced selectivity. The selection of pantoprazole as a clinical candidate》. The article mentions the following:
[(Pyridylmethyl)sulfinyl]benzimidazoles I (R = OCF2H, OCH2CF3, OCF2CF2H; R1 = H, OMe; RR1 = OCF2O; R2, R3 = H, Me, OMe) were prepared and tested for (H+,K+)-ATPase inhibitory activity. The aim of this study was to identify compounds with high (H+,K+)-ATPase inhibitory activity in stimulated gastric glands possessing acidic pH, but low reactivity (high chem. stability) at neutral pH as reflected by in vitro (Na+,K+)-ATPase inhibitory activity. The critical influence of substituents flanking the pyridine 4-MeO substituent present in all derivatives was carefully studied. The introduction of a 3-MeO group gave inhibitors possessing a combination of high potency, similar to omeprazole and lansoprazole, but increased stability. As a result I (R = OCF2H, R1 = R3 = H, R2 = OMe; pantoprazole) was selected as a candidate drug and is currently undergoing phase III clin. studies. In the experimental materials used by the author, we found 2-(Chloromethyl)-4-methoxypyridine hydrochloride(cas: 62734-08-1Name: 2-(Chloromethyl)-4-methoxypyridine hydrochloride)
2-(Chloromethyl)-4-methoxypyridine hydrochloride(cas: 62734-08-1) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Name: 2-(Chloromethyl)-4-methoxypyridine hydrochloride