Kokhan, Serhii O.; Valter, Yevheniia B.; Tymtsunik, Andriy V.; Komarov, Igor V.; Grygorenko, Oleksandr O. published the artcile< 3-Carboxy-/3-Aminobicyclo[1.1.1]pentane-Derived Sulfonamides and Sulfonyl Fluorides - Advanced Bifunctional Reagents for Organic Synthesis and Drug Discovery>, Computed Properties of 3811-73-2, the main research area is carboxy aminobicyclopentane derived sulfonamide sulfonyl fluoride preparation.
A convenient approach to 1,3-bifunctional sulfonyl fluorides, sulfonamides and sulfinates bearing a bicyclo[1.1.1]pentane unit attached to the sulfur atom and (protected) amino or carboxyl group is described. The method relied on photochem. decomposition of Barton [1-hydroxypyridine-2(1H)-thione] esters of the corresponding carboxylic acids as the key step, followed by oxidation and cleavage of the 2-pyridyl moiety. The title building blocks were obtained on a gram scale, and their utility was demonstrated by preparation of an isosteric analog of classical sulfonamide anitibiotic sulfanilamide, as well as some other common chem. modifications.
European Journal of Organic Chemistry published new progress about Sulfinates Role: SPN (Synthetic Preparation), PREP (Preparation). 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, Computed Properties of 3811-73-2.