Fluorenone Schiff base derivative complexes of ruthenium, rhodium and iridium exhibiting efficient antibacterial activity and DNA-binding affinity was written by Kollipara, Mohan Rao;Shadap, Lathewdeipor;Banothu, Venkanna;Agarwal, Nipanshu;Poluri, Krishna Mohan;Kaminsky, Werner. And the article was included in Journal of Organometallic Chemistry in 2020.Computed Properties of C12H9NO This article mentions the following:
Half-sandwich ruthenium, rhodium and iridium pyridyl fluorenylidene azine Schiff base complexes [LMCl(2-pyCR:NN:Fl)] (1–9; M = Ru, L = p-cymene; M = Rh, Ir, L = C5Me5; R = Ph, Me, H; py = pyridyl, Fl = 9-fluorenylidene) were prepared and examined for their antibacterial activity. Metal precursors [(arene)MCl2]2 (arene = p-cymene, Cp*; M = Ru, Rh and Ir) on reacting with 9-fluorenone derivative ligands L1, L2 and L3 resulted in the formation of mononuclear bidentate cationic N-N bonded complexes. The biol. studies of these complexes such as antibacterial activity studies (against Gram-pos. and Gram-neg. bacteria) revealed significant antibacterial activity with complexes 4, 7 and 9 having the highest activity potency (in-vitro). While for DNA-binding studies, the results revealed that complexes 4 and 5 displayed significant changes in their spectral features upon addition of SM-DNA, thus, indicating that these complexes bind to DNA with a significant affinity. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Computed Properties of C12H9NO).
Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Computed Properties of C12H9NO