On May 19, 2022, Kopf, Sara; Liu, Jiali; Franke, Robert; Jiao, Haijun; Neumann, Helfried; Beller, Matthias published an article.Recommanded Product: 109660-12-0 The title of the article was Base-Mediated Remote Deuteration of N-Heteroarenes – Broad Scope and Mechanism. And the article contained the following:
Using KOtBu as base and DMSO-d6 as deuterium source, a general and applicable method was presented for the selective deuteration of a set of nitrogen-containing heterocycles (pyridines, azines and bioactive mols.). Exptl. and DFT mechanistic studies indicated that this reaction proceeded via deprotonation of the substrates by the dimsyl anion. The relative thermodn. stability of the heterocycle anions determines the distribution and degree of deuteration. The experimental process involved the reaction of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine(cas: 109660-12-0).Recommanded Product: 109660-12-0
The Article related to heteroarene deuterated dimethyl sulfoxide regioselective deuteration, deuterated heteroarene preparation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Recommanded Product: 109660-12-0