Application In Synthesis of Methyl 3-chloropicolinateOn June 1, 2015, Kozlov, Maxim V.; Kleymenova, Alla A.; Romanova, Lyudmila I.; Konduktorov, Konstantin A.; Kamarova, Kamila A.; Smirnova, Olga A.; Prassolov, Vladimir S.; Kochetkov, Sergey N. published an article in Bioorganic & Medicinal Chemistry Letters. The article was 《Pyridine hydroxamic acids are specific anti-HCV agents affecting HDAC6》. The article mentions the following:
Recently we reported benzohydroxamic acids (BHAs) as potent and selective inhibitors of hepatitis C virus (HCV) replicon propagation. In this work 12 pyridine hydroxamic acids (PHAs) e. g., I, were synthesized and tested in full-genome replicon assay. It was found that PHAs possessed very similar anti-HCV properties compared to BHAs. Both classes of hydroxamic acids caused hyperacetylation of α-tubulin pointing to inhibition of histone deacetylase 6 (HDAC6) as part of their antiviral activity. The tested compounds did not inhibit the growth of poliovirus, displaying high selectivity against HCV. After reading the article, we found that the author used Methyl 3-chloropicolinate(cas: 116383-98-3Application In Synthesis of Methyl 3-chloropicolinate)
Methyl 3-chloropicolinate(cas: 116383-98-3) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Application In Synthesis of Methyl 3-chloropicolinate