Kress, Thomas J.; Moore, Larry L.; Costantino, Silvio M. published the artcile< Selective chlorinations in sulfuric acid. Synthesis of some 2-amino-5-chloro-, 2-amino-3-chloro-, and 2-amino-3,5-dichloropyridines>, Application In Synthesis of 22280-62-2, the main research area is pyridine amino chlorination; chlorination aminopyridine sulfuric acid.
Addnl. data considered in abstracting and indexing are available from a source cited in the original document. 2-Aminopyridine and a number of Me substituted 2-aminopyridines underwent selective chlorination. The chlorination of 2-aminopyridine at various H2SO4 concentrations and the distribution of chlorinated products was studied in detail. With increasing acidity dichlorination decreases, and in 72% H2SO4 only traces of dichlorination occur. The selectivity of the chlorination reaction is ascribed to differences in the rate of chlorination of protonated vs nonprotonated substrates.
Journal of Organic Chemistry published new progress about Chlorination. 22280-62-2 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Application In Synthesis of 22280-62-2.