Kritchevsky, D.; Tepper, S. A. published an article in 1964, the title of the article was Oxidation of cholesterol-26-14C by rat liver mitochondria: effect of compounds related to nicotinic acid and nicotinamide.Category: pyridine-derivatives And the article contains the following content:
cf. CA 58, 840f. Nicotinamide homologs were tested to determine their effect on the oxidation of labeled cholesterol and compared to nicotinic acid; also examined were ω-3-pyridylacrylic acid and picolinic and 3-pyridinesulfonic acids. The reaction mixtures were prepared according to Kritchevsky, et al. (CA 54, 11177d; 11204i), and Whitehouse, et al. (CA 53, 9422b). The percentage oxidation of cholesterol-26-14C was calculated as counts per min. of 14CO2 (as Ba14CO3) evolved during an 18-hr. incubation at 37° per 100 counts per min. of cholesterol-26-14C. Nicotinic acid showed high oxidation enhancing, but none of the amides (acetyl, propionyl, and acrylyl) had any effect. Data indicate that a free carboxyl group is necessary for stimulation of oxidation Picolinic and 3-pyridinesulfonic acids enhanced oxidation to a small extent while ω-3-pyridylacrylic acid had no in vitro effect. The nonacting compounds had no chelating action. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Category: pyridine-derivatives
Pyridine-3-sulfonic acid(cas:636-73-7) belongs to pyridine-derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Category: pyridine-derivatives