In 2022,Kullmer, Cesar N. Prieto; Kautzky, Jacob A.; Krska, Shane W.; Nowak, Timothy; Dreher, Spencer D.; MacMillan, David W. C. published an article in Science (Washington, DC, United States). The title of the article was 《Accelerating reaction generality and mechanistic insight through additive mapping》.SDS of cas: 3510-66-5 The author mentioned the following in the article:
Reaction generality is crucial in determining the overall impact and usefulness of synthetic methods. Typical generalization protocols require a priori mechanistic understanding and suffer when applied to complex, less understood systems. An additive mapping approach that rapidly expands the utility of synthetic methods while generating concurrent mechanistic insight was developed. Validation of this approach on the metallaphotoredox decarboxylative arylation resulted in the discovery of a phthalimide ligand additive that overcomes many lingering limitations of this reaction and has important mechanistic implications for nickel-catalyzed cross-couplings. After reading the article, we found that the author used 2-Bromo-5-methylpyridine(cas: 3510-66-5SDS of cas: 3510-66-5)
2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.SDS of cas: 3510-66-5