《Biotin-tagged cis-dichlorido-oxidovanadium(IV) complex for DNA crosslinking and photo-induced apoptotic cytotoxicity》 was written by Kumar, Arun; Sahoo, Somarupa; Dixit, Akanksha; Karande, Anjali A.; Chakravarty, Akhil R.. COA of Formula: C12H13N3This research focused onvanadium oxo chloro biotin appended dipicolylamine complex preparation anticancer; crystal structure vanadium oxo chloro biotin appended dipicolylamine complex. The article conveys some information:
Cis-dichlorido-oxidovanadium(IV) complexes [VO(dpa/L1)Cl2] (1, 2) of dipicolylamine (dpa, 1 as control species) and 5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid (biotin)-appended dpa (L1, 2 as active species) were prepared and their anticancer activity studied. Single crystal X-ray diffraction anal. of complex 1 revealed a cis arrangement of two chloride ligands in a distorted octahedral geometry with VIVON3Cl2. The dpa ligand displayed a facial mode of coordination. The complexes were 1:1 electrolytic in an aqueous medium and showed a significant enhancement of conductivity on irradiation with visible light. Complex 2 having the biotin moiety showed cytotoxicity in visible light of 400-700 nm giving IC50 value of 15.0(±0.2) μM in HeLa cells and 5.0(±1.2) μM in HepG2 cells. The complex did not show any apparent generation of reactive oxygen species (ROS) in dichlorofluorescein diacetate (DCFDA) assay. The complex displayed apoptotic photo-induced cytotoxicity following DNA crosslinking pathway as ascertained from the comet assay. In the experiment, the researchers used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0COA of Formula: C12H13N3)
Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.COA of Formula: C12H13N3