Kurose, Ayako; Ishida, Yuto; Hirata, Goki; Nishikata, Takashi published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Direct α-Tertiary Alkylations of Ketones in a Combined Copper-Organocatalyst System》.Product Details of 1122-54-9 The article contains the following contents:
Herein, we report an efficient method for the tertiary alkylation of a ketone by using an α-bromocarbonyl compound as the tertiary alkyl source in a combined Cu-organocatalyst system. This dual catalyst system enables the addition of a tertiary alkyl radical to an enamine. Mechanistic studies revealed that the catalytically generated enamine is a key intermediate in the catalytic cycle. The developed method can be used to synthesize substituted 1,4-dicarbonyl compounds containing quaternary carbons bearing various alkyl chains. The experimental process involved the reaction of 4-Acetylpyridine(cas: 1122-54-9Product Details of 1122-54-9)
4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Product Details of 1122-54-9