《Synthesis, characterization, DNA interaction and docking studies of novel Schiff base ligand derived from 2,6-diaminopyridine and its complexes》 was written by Kurt, Baris; Temel, Hamdi; Atlan, Metin; Kaya, Savas. Category: pyridine-derivativesThis research focused ontransition metal Schiff diaminopyridine hydroxynaphthalenylmethylideneaminophenylethanone complex preparation thermal stability; magnetic susceptibility DNA binding transition metal Schiff diaminopyridine hydroxynaphthalenylmethylideneaminophenylethanone. The article conveys some information:
In this study 1-(4-{[(3-hydroxynaphthalen-2-yl)methylidene]amino}phenyl)ethan-1-one (B1 ligand) were synthesized from the reaction of 2-hydroxy-1-naphthaldehyde with 4-amino-acetophenone. Following that 1-(N-{4-[(1)-1-({6-[(Z)-[1-(4-{[(3- hydroxynaphthalen-2-yl) methylidene]amino}phenyl)ethylidene]amino]pyridin-2- yl}imino)ethyl]phenyl}carboximidoyl)naphthalen-2-ol (L1 ligand) were synthesized from the reaction of 2,6-diamino pyridine with B1 ligand. Using this Schiff base ligand Cu(II), Fe(II) and Pd(II) complexes were prepared The structure of the ligand and its complexes were determined by 1H NMR, FTIR, UV-Vis, elemental anal., thermal analyses and magnetic susceptibility spectral data. Further, DNA binding properties of the ligand and its metal complexes were investigated and docking studies were carried out. As a result ligands and copper complex showed DNA binding activity and an increase with H2O2. According to these results it can be suggested that these compounds are very suitable drug candidates. The results came from multiple reactions, including the reaction of 2,6-Diaminopyridine(cas: 141-86-6Category: pyridine-derivatives)
2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Category: pyridine-derivatives