In 2009,Kuwabara, Junpei; Mori, Hironori; Teratani, Takuya; Akita, Munetaka; Kanbara, Takaki published 《Regioregulated Syntheses of Poly(aminopyridine)s by Pd-catalyzed Amination Reaction》.Macromolecular Rapid Communications published the findings.SDS of cas: 13534-97-9 The information in the text is summarized as follows:
Regioregulated poly(aminopyridine)s were synthesized by a Pd-catalyzed C-N coupling reaction. The polymerization using Pd(0) and a bulky monodentate phosphine ligand distinctively produced the para-linked and meta-linked poly(aminopyridine)s, without the need for a protection process. The regioregularity of the polymer was confirmed by 1H NMR spectroscopy. Model reactions were studied to evaluate the possibility of crosslinkage in the polymer. A large difference in reactivity was observed between 5-amino-2-bromopyridine and 2-amino-5-bromopyridine, which should have afforded same product. D. functional theory (DFT) calculations indicated that electron densities of the Br-bound carbon atom and the pyridine-nitrogen atom determine the reactivity of the monomers. The experimental part of the paper was very detailed, including the reaction process of 6-Bromopyridin-3-amine(cas: 13534-97-9SDS of cas: 13534-97-9)
6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.SDS of cas: 13534-97-9