Lai, Long-Li; Lin, Pen-Yuan; Wang, Jy-Shih; Hwu, Jih Ru; Shiao, Min-Jen; Tsay, Shwu-Chen published the artcile< Substituent effect on the chlorination of 2-alkoxypyridines to give 2-chloropyridines under Vilsmeier-Haack conditions>, Synthetic Route of 13472-84-9, the main research area is substituent effect chlorination alkoxypyridine.
Various substituted 2-alkoxypyridines were converted into the corresponding 2-chloropyridines in 28-91% yield by use of POCl3 and DMF. Me, halogen, ester and nitro groups displayed an activating effect and an amino group exhibited a deactivating effect.
Journal of Chemical Research, Synopses published new progress about Chlorination. 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, Synthetic Route of 13472-84-9.