Lai, Ping-Shan; Jansen-van Vuuren, Ross D.; Lemieux, Robert P.; Snieckus, Victor published their research in Journal of Organic Chemistry in 2021. The article was titled 《Directed ortho and Remote Metalation-Suzuki-Miyaura Cross Coupling Route to Azafluorenol Core Liquid Crystals》.Application In Synthesis of 2,5-Dibromopyridine The article contains the following contents:
Two new smectic C* (SmC*) mesogens containing a hexyloxy side chain and an azafluorenone I or azafluorenol II core were synthesized using a combined directed ortho metalation-directed remote metalation-Suzuki-Miyaura cross-coupling strategy. The II was formed in 9 steps and 25% overall yield based on starting N,N-diethyl-3-methoxybenzamide. The I forms a nematic (N) phase while II forms a smectic A (SmA) phase. The large temperature range of the Sm phase for the azafluorenol II is indicative of mesophase stabilization by intermol. hydrogen bonding between the hydroxyl group and pyridine nitrogen. In the experimental materials used by the author, we found 2,5-Dibromopyridine(cas: 624-28-2Application In Synthesis of 2,5-Dibromopyridine)
2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Application In Synthesis of 2,5-Dibromopyridine