Lai, Yin-Long; Yan, Shaoxi; He, Dan; Zhou, Li-Zhen; Chen, Zi-Shen; Du, Yu-Long; Li, Jianxiao published their research in RSC Advances in 2021. The article was titled 《Palladium-catalyzed bisthiolation of terminal alkynes for the assembly of diverse (Z)-1,2-bis(arylthio)alkene derivatives》.Application of 2510-22-7 The article contains the following contents:
An efficient and straightforward palladium-catalyzed three-component cascade bisthiolation of terminal alkynes RCCH (R = n-Pr, Ph, cyclohexyl, 2-thienyl, etc.) and arylhydrazines ArNH2NH2.HCl (Ar = Ph, 4-fluorophenyl, 3-thienyl, etc.) with sodium thiosulfate (Na2S2O3) as the sulfur source for the assembly of functionalized (Z)-1,2-bis(arylthio)alkene derivatives RC(SAr)=CH(SAr) is described. Using 0.5 mol% IPr-Pd-Im-Cl2 as the catalyst, a wide range of terminal alkynes and arylhydrazines are well tolerated, thus producing the desired products in good yields with good functional group tolerance and excellent regioselectivity. Moreover, this protocol could be readily scaled up, showing potential applications in organic synthesis and material science. In the experiment, the researchers used 4-Ethynylpyridine(cas: 2510-22-7Application of 2510-22-7)
4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Application of 2510-22-7