Lamani, Devappa S.; Badiger, Srikant G.; Singh, Mamata published the artcile< Formation of diaryl sulfides and sulfoxides: Synthesis, characterization and structure activity correlation studies>, Related Products of 3731-53-1, the main research area is diarylsulfide preparation glutathione peroxidase mimetic activity; diarylsulfoxide preparation glutathione peroxidase mimetic activity.
The synthesis of a series of diarylsulfides I [R = C(Me)2CH2OH, 3-pyridyl, 4-MeOC6H4CH2, etc.; X= S] was achieved by reaction of 2,2′-thiobis[benzoyl chloride] with amines followed by the presence of H2O2/t-BuOOH to afford corresponding sulfoxides II [X= S=O]. All the newly synthesized compounds were characterized by 1H, 13C NMR and mass spectroscopic techniques. A detailed mechanistic study indicated that the formation of sulfoxides followed oxidation In addition to synthesis, characterization and mechanistic studies, the glutathione peroxidase(GPx) mimetic activity of the newly synthesized compounds was described. It was observed that the diaryl sulfides having a heterocyclic ring attached to the nitrogen atom facilitated the oxidation of the sulfur center to form the corresponding sulfoxides. The substituents attached to the nitrogen atom played an important role in the catalytic activity of substituted diaryl sulfides. The obtained data supported for the higher antioxidant activity of diaryl sulfides than that of the corresponding sulfoxides.
Phosphorus, Sulfur and Silicon and the Related Elements published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Related Products of 3731-53-1.