Lamers, Philip published the artcileTetrahydrobenzo[c]thieno[2,1-e]isothiazole 4-Oxides: Three-Dimensional Heterocycles as Cross-Coupling Building Blocks, Related Products of pyridine-derivatives, the publication is Organic Letters (2018), 20(1), 116-118, database is CAplus and MEDLINE.
Tetrahydrobenzothienoisothiazole oxides such as I (R = H, I, Br, F, Cl, NC, MeO2C, O2N, F5S, F3C), cyclic sulfoximines, were prepared as novel heterocycles amenable to cross-coupling reactions and automated parallel synthesis. Reaction of tetrahydrothiophene with anilines such as 4-RC6H4NH2 (R = H, I, Br, F, Cl, NC, MeO2C, O2N, F5S, F3C) mediated by N-chlorosuccinimide (NCS) and Et3N in CH2Cl2 yielded (tetrahydrothienyl)anilines such as II (R = H, I, Br, F, Cl, NC, MeO2C, O2N, F5S, F3C) in 29-89% yields; tetrahydrothiopyran, N-Boc thiomorpholine, and 1,4-thioxane yielded thioether-substituted anilines, but the products did not undergo oxidative cyclocondensation. Further oxidation of (tetrahydrothienyl)anilines with N-chlorosuccinimide, treatment with aqueous NaOH, and oxidation with meta-chloroperbenzoic acid (mCPBA) yielded such as I (R = H, I, Br, F, Cl, NC, MeO2C, O2N, F5S, F3C). I (R = I, Br) and related tetrahydrobenzothienoisothiazole oxides underwent borylation, Sonogashira, and Suzuki coupling reactions.
Organic Letters published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Related Products of pyridine-derivatives.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem