Lauro, Figueroa-Valverde published the artcileEvaluation of Biological Activity of a Diazocine Derivative against Heart Failure Using an Ischemia-Reperfusion Injury Model, Name: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, the main research area is heart failure ischemia reperfusion injury diazocine.
BackgroundThere are studies, which suggest that some diazocine derivatives can exert effects on the cardiovascular system; however, these effects are not very clear. ObjectiveThe aim of this research was to evaluate the biol. activity of a diazocine derivative against heart failure translated as area infarct. MethodsBiol. activity produced by diazocine derivatives against heart failure was determinate using an ischemia/reperfusion injury model. Besides, to characterize the mol. mechanism of effect exerted by diazocine derivative on left ventricular pressure (LVP) was determinate in an isolated rat heart model using nifedipine, PINAME TXA 2, and quinalizarin as controls. ResultsThe results showed that diazocine derivative decrease the infarct area and increase the LVP. However, the effect produced by diazocine derivative on LVP was inhibited in the presence of quinalizarin. ConclusionsThe results indicate that biol. activity produced by diazocine derivative on left ventricular pressure is through protein CK2 activation; this phenomenon could be translated as a decrease in both infarct area and heart failure.
Drug Research (Stuttgart, Germany) published new progress about Biology. 21829-25-4 belongs to class pyridine-derivatives, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Name: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.