《Zooming in on the hydrated imidazoline ring expansion: Factors influencing the rate of N → N’ aroyl migration in N-aroyl-N-(hetero)aryl ethylenediamines》 was written by Lavit, Kseniya; Reutskaya, Elena; Grintsevich, Sergey; Sapegin, Alexander; Krasavin, Mikhail. Product Details of 197958-29-5 And the article was included in Tetrahedron Letters in 2020. The article conveys some information:
The influence of electronic factors on the rates of N → N’ aroyl migration in N-aroyl-N-(hetero)aryl ethylenediamines was examined Electron-withdrawing substituents on the aroyl group weakly accelerate the reaction (in linear correlation with the Hammett σp constants). Much stronger influence came from the nitrogen-bound aromatic group which gave a strong linear correlation with the Hammett σ-p constants For electron-deficient heteroaromatics and nitroaroms., the migration was nearly instantaneous in basic medium. These findings will significantly impact the planning of mechanistically related transformations of N-(2-aminoethyl) lactams through the hydrated imidazoline ring expansion (HIRE) process. The results came from multiple reactions, including the reaction of 2-Pyridinylboronic acid(cas: 197958-29-5Product Details of 197958-29-5)
2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Product Details of 197958-29-5