On June 1, 2018, Le, Chip; Chen, Tiffany Q.; Liang, Tao; Zhang, Patricia; MacMillan, David W. C. published an article.Synthetic Route of 2229858-27-7 The title of the article was A radical approach to the copper oxidative addition problem: Trifluoromethylation of bromoarenes. And the article contained the following:
Transition metal-catalyzed arene functionalization was widely used for mol. synthesis over the past century. In this arena, copper catalysis has long been considered a privileged platform due to the propensity of high-valent copper to undergo reductive elimination with a wide variety of coupling fragments. However, the sluggish nature of oxidative addition has limited copper’s capacity to broadly facilitate haloarene coupling protocols. Here, this copper oxidative addition problem can be overcome with an aryl radical-capture mechanism, wherein the aryl radical was generated through a silyl radical halogen abstraction. This strategy was applied to a general trifluoromethylation of aryl bromides through dual copper-photoredox catalysis. Mechanistic studies support the formation of an open-shell aryl species. The experimental process involved the reaction of 4,4′-Bis(trifluoromethyl)-2,2′-bipyridinebis[3,5-difluoro-2-[5-methyl-2-pyridinyl)phenyl] iridium(III) hexafluorophosphate(cas: 2229858-27-7).Synthetic Route of 2229858-27-7
The Article related to copper oxidative addition trifluoromethylation bromoarene, Physical Organic Chemistry: General and other aspects.Synthetic Route of 2229858-27-7