Leal-Junior, Carlos C. published the artcileEffectiveness of an oral versus sublingual loading dose of nifedipine for tocolysis, HPLC of Formula: 21829-25-4, the main research area is nifedipine tocolytic oral sublingual drug delivery premature labor; Nifedipine; Oral administration; Pregnant; Premature; Premature labor; Sublingual administration; Tocolysis.
Objective : To determine the effectiveness of an oral vs. sublingual loading dose of nifedipine for tocolysis. Methods : An open, randomized clin. trial conducted between March 1, 2013, and Apr. 31, 2014. Participants were pregnant women with a diagnosis of premature labor, single live fetus, topical pregnancy, gestational age 24-36 wk, normal fetal vitality, cervical dilatation less than or equal to 4 cm, cervical effacement less than or equal to 80%, and intact amniotic membranes. They were randomized into two groups, oral and sublingual nifedipine, 20 mg loading dose, repeated every 30 min (maximum dose of 60 mg). The primary endpoint was the time until tocolysis and the secondary endpoints were the effectiveness of tocolysis within 90 min, 12 h, and 48 h; premature delivery within 48 h; and maternal hemodynamic parameters and side effects. Results : There were 80 patients randomized to oral (n=40) and sublingual (n=40) nifedipine. The time required for tocolysis was significantly less with sublingual nifedipine (160 min vs 340 min; P=0.0003). Sublingual nifedipine was also more successful than oral nifedipine at inhibiting premature labor within 90 min (n=8 [20.0%] vs n=1 [2.5%], P=0.014). There was no statistically significant difference between the groups for the other secondary endpoints. Conclusion : Compared with oral administration, a sublingual loading dose of nifedipine resulted in faster tocolysis in patients with premature labor. Brazilian Clin. Trials Registry (ReBEC): U1111-11566186.
International Journal of Gynecology & Obstetrics published new progress about Amnion, epithelium. 21829-25-4 belongs to class pyridine-derivatives, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, HPLC of Formula: 21829-25-4.