Name: 3-Cyanopyridine《Decarbonylative Synthesis of Aryl Nitriles from Aromatic Esters and Organocyanides by a Nickel Catalyst》 was published in 2021. The authors were Iizumi, Keiichiro;Kurosawa, Miki B.;Isshiki, Ryota;Muto, Kei;Yamaguchi, Junichiro, and the article was included in《Synlett》. The author mentioned the following in the article:
A decarbonylative cyanation of aromatic esters with aminoacetonitriles in the presence of a nickel catalyst were developed. The key to this reaction were the use of a thiophene-based diphosphine ligand, dcypt, permitting the synthesis of aryl nitrile without the generation of stoichiometric metal- or halogen-containing chem. wastes. A wide range of aromatic esters, including hetarenes and pharmaceutical mols., were converted into aryl nitriles. To complete the study, the researchers used 3-Cyanopyridine (cas: 100-54-9) .
3-Cyanopyridine(cas: 100-54-9) also shows biological activity against autoimmune diseases, such as murine hepatitis, by inhibiting the proliferation of B cells and T cells.Name: 3-Cyanopyridine This drug is not effective against cancer cells because it does not inhibit DNA synthesis or protein synthesis.