On August 25, 2022, Lee, Hee Jin; Park, Jin Young; Lee, Hye Mi; Yang, Deok Mo; Nam, Eun Hye; Kim, Hak Do; Jung, Hui Jin; Choung, Won Ken published a patent.SDS of cas: 868551-99-9 The title of the patent was Preparation of pyrimidine-fused ring compounds with DNA-PK inhibition activity and use thereof. And the patent contained the following:
The invention relates to a pyrimidine-fused ring compounds of formula I, stereoisomers, pharmaceutically acceptable salts, or pharmaceutical compositions thereof that are useful for the prevention or treatment of cancer. The pyrimidine-fused ring compounds of the present invention exhibits excellent inhibitory activity against DNA-PK and thus can be advantageously used as a therapeutic agent for DNA-PK-related diseases. Compounds of formula I wherein the normalized bond is a single or double bond; n is 0-2; X1 is NR1 or CR2R3; X2 and X3 are independently -CR2R3-, -CR2-, -(C=O)-, or -(C=S)-; L1 is null or alkylene; Y is alkoxy, Q1, Q2, or (un)substituted (hetero)aryl; W1 is -CH2-, -NH-, -O-, or -S-; W2 is -CH- or -N-; a – d are independently 0-3; L2 is null or alkylene; Z is -Z1-L3-Z2; Z1 is (un)substituted (hetero)aryl or (un)substituted benzene-fused ring; L3 is alkylene, -(C=O)-, -(C=O)NH-, -NH-, etc.; Z2 is H, alkyl, hydroxyalkyl, alkoxyalkyl, etc.; R is H or alkyl; R1 – R3 are independently H or alkyl; are claimed. Example compound II was prepared by palladium-catalyzed cross-coupling reaction of 2-chloro-7-methyl-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one with 2,5-dimethylbenzo[d]thiazol-6-amine in 11% yield. The invention compounds were evaluated for the DNA-pk inhibition activity (biol. data given). The experimental process involved the reaction of Methyl 5-amino-4-methylpicolinate(cas: 868551-99-9).SDS of cas: 868551-99-9
The Article related to pyrimidine fused ring preparation dnapk inhibition cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.SDS of cas: 868551-99-9