ACS Catalysis published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Application In Synthesis of 18437-58-6.
Lee, Li-Chen published the artcileFunctionalized polymer-supported pyridine ligands for palladium-catalyzed C(sp3)-H arylation, Application In Synthesis of 18437-58-6, the publication is ACS Catalysis (2016), 6(8), 5245-5250, database is CAplus.
Palladium trifluoroacetate, ligated to polymer-anchored 2-methylpyridine ligands, catalyzed C(sp3)-H bond activation and arylation of N-phthalimido-L-alaninamide with iodoarenes ArI, giving monoarylated products, ArCH2CH(NPhth)CONHArF (2, Phth = 1,2-(CO)2C6H4, ArF = 4-CF3C6H4). The use of ligands to tune the reactivity and selectivity of transition-metal catalysts for C(sp3)-H bond activation is a current central challenge. One of us previously developed an uncommon example of a homogeneous catalyst that performs controlled C(sp3)-H arylation using pyridine derivatives as ligands, along with Pd [Science, 2014, 343, 1216-1220]. In this work, we report a functionalizable and tunable polymer support used in the immobilization of pyridine derivatives that yields a soluble, polymeric ligand platform facilitating C(sp3)-H activation reactions with good yields, selectivities differing from the homogeneous catalyst, and recovery of Pd. Unlike the homogeneous system, the supported catalysts in Pd-catalyzed C-H monoarylation reactions respond sensitively to the steric hindrance of the coupling partners.
ACS Catalysis published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Application In Synthesis of 18437-58-6.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem