2-(2-Chloro-6-fluorophenyl)acetamides as potent thrombin inhibitors was written by Lee, Lily;Kreutter, Kevin D.;Pan, Wenxi;Crysler, Carl;Spurlino, John;Player, Mark R.;Tomczuk, Bruce;Lu, Tianbao. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Application of 199296-39-4 This article mentions the following:
2-(2-Chloro-6-fluorophenyl)acetamides having 2,2-difluoro-2-aryl/heteroaryl-ethylamine P3 and oxyguanidine P1 substituents are potent thrombin inhibitors (Ki = 0.9-33.9 nM). 2-(5-Chloropyridin-2-yl)-2,2-difluoroethylamine was the best P3 substituent, yielding the most potent inhibitor (Ki = 0.7 nM). Replacing the P3 heteroaryl group with a Ph ring or replacing the difluoro substitution with di-Me or cyclopropyl groups in the linker reduced the affinity for thrombin significantly. The aminopyridine P1s also provided an increase in potency. In the experiment, the researchers used many compounds, for example, 2-Methyl-2-(pyridin-2-yl)propan-1-amine (cas: 199296-39-4Application of 199296-39-4).
2-Methyl-2-(pyridin-2-yl)propan-1-amine (cas: 199296-39-4) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Application of 199296-39-4