Lee, So Jeong; Morales-Colon, Maria T.; Brooks, Allen F.; Wright, Jay S.; Makaravage, Katarina J.; Scott, Peter J. H.; Sanford, Melanie S. published their research in Journal of Organic Chemistry in 2021. The article was titled 《SNAr Radiofluorination with In-Situ Generated [18F]Tetramethylammonium Fluoride》.Recommanded Product: 53939-30-3 The article contains the following contents:
This report described a method for the nucleophilic radiofluorination of (hetero)aryl chlorides, (hetero)aryl triflates, and nitroarenes using a combination of [18F]KF·K2.2.2 and Me4NHCO3 for the in-situ formation of a strongly nucleophilic fluorinating reagent (proposed to be [18F]Me4NF). This method was applied to 24 substrates bearing diverse functional groups, and it generates [18F](hetero)aryl fluoride products in good to excellent radiochem. yields in the presence of ambient air/moisture. The reaction was applied to the preparation of 18F-labeled HQ-415 for potential (pre)clin. use. In the part of experimental materials, we found many familiar compounds, such as 5-Bromo-2-chloropyridine(cas: 53939-30-3Recommanded Product: 53939-30-3)
5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Recommanded Product: 53939-30-3