Lei Lu, Tan;Shahriman, Mohamad Shariff;Sambasevam, Kavirajaa Pandian;Mohamad Zain, Nur Nadhirah;Yahaya, Noorfatimah;Lim, Vuanghao;Raoov, Muggundha published 《In-tip solid-phase microextraction: a method for determination of sulphonamide residues in environmental water samples》 in . The article was appeared in 《International Journal of Environmental Analytical Chemistry》. They have made some progress in their research.Category: pyridine-derivatives The article mentions the following:
This study involved the development of an in-pipet tip solid-phase microextraction (SPME) method using activated charcoal as an adsorbent. Simultaneous determination of three sulfonamide antibiotic residues in environmental water was performed using this method, coupled with high-performance liquid chromatog.-photodiode array (HPLC-PDA) detection. Seven extraction parameters were optimized by one-variable-at-a-time (OVAT) and response surface (RSM) methods. Optimum extraction efficiency was achieved when 10 mL of sample solution at a natural pH (pH 5-6) was loaded through a 1 mL pipet tip packed with 10 mg of adsorbent, washed with 1 mL of hexane and eluted with 500 μL of 1% ammonium in methanol solution Under the optimized exptl. condition, this method manifested good linearity (5-500 μg L-1) at the coefficient of determination, R2 of 0.9992 to 0.9993, high sensitivity (limit of detection, LOD: 0.38-1.14 μg L-1; limit of quantification, LOQ: 1.14-3.35 μg L-1), and satisfactory recoveries (82.8-108.7%) with acceptable reproducibility (RSD < 4.6%). Real sample anal. of five environmental water samples sourced from Universiti Malaya, Kuala Lumpur and Malacca showed that the samples contained either none or traces of the target sulfonamides (SAs) with their concentration lower than the LOQs. In contrast to other methods, the comparison outcomes depicted that this in-tip SPME method was beneficial in terms of its simple, reusable, cost-saving setup together with a significant reduction in chem. consumption. The experimental procedure involved many compounds, such as 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .
4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Category: pyridine-derivativesDue to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.