Arylation of benzyl amines with aromatic nitriles was written by Lei, Yingjie;Yang, Ju;Qi, Rupeng;Wang, Shan;Wang, Rui;Xu, Zhaoqing. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2018.Recommanded Product: 3939-14-8 This article mentions the following:
Radical arylations using aromatic nitriles without the assistance of photoirradn was developed. Importantly, with this method, the direct arylation of C(sp3)-H in benzyl amines provided a practical method for the synthesis of diarylmethylamines I [R = H, CN; R1 = H, F, 4-MeOC6H4, etc.; Ar = Ph, 4-ClC6H4, 2-furyl, etc.; X = C-R, N; R = H, CN] without the use of precious transition metal catalysts. In the experiment, the researchers used many compounds, for example, 2-Fluoroisonicotinonitrile (cas: 3939-14-8Recommanded Product: 3939-14-8).
2-Fluoroisonicotinonitrile (cas: 3939-14-8) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Recommanded Product: 3939-14-8