Lengacher, Raphael; Wang, Youchao; Braband, Henrik; Blacque, Olivier; Gasser, Gilles; Alberto, Roger published the artcile< Organometallic small molecule kinase inhibitors - direct incorporation of Re and 99mTc into Opaganib>, Quality Control of 3731-53-1, the main research area is prostate cancer opaganib bioorganometallic complex anticancer mol theranostics.
[(η5-Cp)ReI(CO)3] was incorporated into the kinase inhibitor Opaganib. The resulting bioorganometallic complex showed a similar anti-cancer activity to Opaganib against PC-3 cancer cells. The IC50 value for the kinase SK2 is 30x higher than that of Opaganib. The 99mTc homolog was synthesized, completing a matched-pair for mol. theranostics.
Chemical Communications (Cambridge, United Kingdom) published new progress about Antitumor agents. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Quality Control of 3731-53-1.