Synthetic Route of C5H6BNO2In 2020 ,《Synthesis and characterization of high affinity fluorogenic α-synuclein probes》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Lengyel-Zhand, Zsofia; Ferrie, John J.; Janssen, Bieneke; Hsieh, Chia-Ju; Graham, Thomas; Xu, Kui-ying; Haney, Conor M.; Lee, Virginia M.-Y.; Trojanowski, John Q.; Petersson, E. James; Mach, Robert H.. The article contains the following contents:
Fluorescent small mols. are powerful tools for imaging α-synuclein pathol. in vitro and in vivo. In this work, we explore benzofuranone as a potential scaffold for the design of fluorescent α-synuclein probes. These compounds have high affinity for α-synuclein, show fluorescent turn-on upon binding to fibrils, and display different binding to Lewy bodies, Lewy neurites and glial cytoplasmic inclusion pathologies in post-mortem brain tissue. These studies not only reveal the potential of benzofuranone compounds as α-synuclein specific fluorescent probes, but also have implications for the ways in which α-synucleinopathies are conformationally different and display distinct small mol. binding sites. The experimental process involved the reaction of Pyridin-3-ylboronic acid(cas: 1692-25-7Synthetic Route of C5H6BNO2)
Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Synthetic Route of C5H6BNO2