Non-peptidic 婵?sub>v闁?sub>3 antagonists containing indol-1-ylpropionic acids was written by Leonard, Kristi;Pan, Wenxi;Anaclerio, Beth;Gushue, Joan M.;Guo, Zihong;DesJarlais, Renee L.;Chaikin, Marge A.;Lattanze, Jennifer;Crysler, Carl;Manthey, Carl L.;Tomczuk, Bruce E.;Marugan, Juan Jose. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.COA of Formula: C6H6N2O3 This article mentions the following:
The synthesis and structure/activity relationship of RGD mimetics that are potent inhibitors of the integrin 婵?sub>v闁?sub>3 are described. Indol-1-ylpropionic acids containing a variety of basic moieties at the 5-position, as well as substitutions alpha and beta to the carboxy terminus were synthesized and evaluated. Novel compounds with improved potency have been identified. In the experiment, the researchers used many compounds, for example, 3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2COA of Formula: C6H6N2O3).
3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C闂備胶鍋ㄩ崕鎻掝嚕?in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.COA of Formula: C6H6N2O3