In 2016,Li, Ben; Zhang, Zhiqiang published 《POPd/TBAB co-catalyzed Suzuki cross-coupling reaction of heteroaryl chlorides/bromides with 4-fluorophenylboronic acid in water》.Journal of the Iranian Chemical Society published the findings.Category: pyridine-derivatives The information in the text is summarized as follows:
An organic solvent free and efficient heterogeneous synthesis for bridging heteroaryl halides and 4-fluorophenylboronic acid was studied in aqueous media according to the Suzuki cross-coupling protocol. High yields of heteroaryl-aryl fluorides were successfully obtained with chloro-/bromo-substituted pyridine, thiophene, indole, and indazole in neat water using palladium phosphinous acid complexes (POPd)/tetrabutylammonium bromide (TBAB) as co-catalysts. A possible mechanism for the heterogeneous coupling reaction was proposed and discussed according to the function of the TBAB interphases. The notable properties of the reported method were highly co-catalytic activity, hetero-atom tolerance, simple separating procedure and little environmental disposal impact. The results came from multiple reactions, including the reaction of 6-Bromopyridin-3-amine(cas: 13534-97-9Category: pyridine-derivatives)
6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Category: pyridine-derivatives