Li, Bowen; Luo, Bangke; Yang, He; Tang, Wenjun published an article in 2022. The article was titled 《Heck Reaction of N-Heteroaryl Halides for the Concise Synthesis of Chiral α-Heteroaryl-substituted Heterocycles》, and you may find the article in Angewandte Chemie, International Edition.Name: Methyl 5-bromopicolinate The information in the text is summarized as follows:
The Heck reaction between N-heteroaryl halides and heterocyclic alkenes provides a convenient approach to biol. relevant α-heteroaryl functionalized heterocycles, yet reactions of this type have been challenging due to strong N-heteroaryl coordination to palladium metal, which causes catalyst poisoning. In this report, an efficient palladium-catalyzed Heck reaction between N-heteroaryl halides and heterocyclic olefins is established, leading to a variety of α-heteroaryl substituted heterocycles. The method features an unprecedented broad substrate scope and excellent functional group compatibility. The employment of a sterically bulky P, P=O ligand containing an anthryl moiety is crucial for this transformation due to the coordinative unsaturation facilitated by its steric bulkiness. The asym. variant of the Heck reaction is achieved with (S)-DTBM-SEGPHOS via a cationic palladium pathway, which has enabled an efficient asym. synthesis of (S)-nicotine and its analogs. In the experimental materials used by the author, we found Methyl 5-bromopicolinate(cas: 29682-15-3Name: Methyl 5-bromopicolinate)
Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Name: Methyl 5-bromopicolinate